10 December 2025, 03:00 am — 05:00 am
IMTGT Room, BPA Building, USU
The Doctoral Promotion Examination of the Doctoral Program in Pharmaceutical Sciences USU by Minda Sari Lubis presents research on salicylic acid–Aloe vera transethosome gel for acne therapy.
DOCTORAL PROMOTION EXAMINATION (OPEN DEFENSE)
DOCTORAL PROGRAM IN PHARMACEUTICAL SCIENCES
FACULTY OF PHARMACY, UNIVERSITAS SUMATERA UTARA
Doctoral Candidate:
MINDA SARI LUBIS
“The Potential of Salicylic Acid Transethosome Gel with Aloe vera (Aloe vera L.) Gel Concentrate for Acne Treatment”
Chair of the Examination:
Prof. Dr. Muryanto Amin, S.Sos., M.Si. (Rector of USU)
Supervisory Committee:
Prof. Dr. Julia Reveny, M.Si., Apt. (Promoter)
Prof. Dr. Poppy Anjelisa Z. Hasibuan, M.Si., Apt. (Co-Promoter)
Prof. Dr. Anayanti Arianto, M.Si., Apt. (Co-Promoter)
Examiners Outside the Committee:
Prof. Dr. Sumaiyah, M.Si., Apt. (Examiner)
Prof. Yuandani, M.Si., Ph.D., Apt. (Examiner)
Dr. T. Ismanelly Hanum, M.Si., Apt. (Examiner)
Dr. Endang Sulistyarini Gultom, M.Si., Apt. (Examiner)
Day/Date:
Wednesday / 10 December 2025
Time:
10.00 WIB – finish
Venue:
IMTGT Room, BPA Building, USU
Brief Description of the Doctoral Candidate’s Dissertation:
Salicylic acid and Aloe vera gel concentrate (KGLB) possess antibacterial activity against acne-causing bacteria Propionibacterium acnes and Staphylococcus epidermidis. Transethosomes are nanovesicles capable of enhancing the permeation of active compounds into the skin. The research aimed to optimize, formulate, characterize, and evaluate the antibacterial activity and anti-acne effectiveness of the salicylic acid–KGLB transethosome gel.
KGLB was obtained through freeze drying and then analyzed phytochemically. The effective concentrations were determined to be 0.5% salicylic acid and 12.5% KGLB. Transethosomes were formulated using the Simplex Lattice Design method and evaluated for their characteristics and antibacterial activity, then incorporated into a gel dosage form. The transethosome gel was evaluated for physical characteristics, stability, chemical interaction using FTIR, antibacterial activity, in vitro release using the basket method, permeation using Franz diffusion cells, and anti-acne effectiveness on rat skin.
KGLB contains saponins, flavonoids, glycosides, tannins, and steroids. KGLB 12.5% and salicylic acid 0.5% exhibited strong antibacterial activity against P. acnes and S. epidermidis. The optimal transethosome formula consisting of 1.5% lecithin, 40% ethanol 96%, 4% Tween-80, and 2% propylene glycol had a desirability value of 0.868. The transethosomes had small particle size, low polydispersity index, stable zeta potential, spherical vesicle morphology, were stable for 12 weeks, and showed inhibition zones around 28 mm. The transethosome gel had standard physical characteristics, stability, no chemical interaction in FTIR analysis, and antibacterial activity around 32 mm. The levels of salicylic acid (95%) and flavonoids (0.130%), release of both active ingredients exceeding 89% at 480 minutes, and declining flux over time. The anti-acne effectiveness was nearly equivalent to Medi-Klin®. The transethosome gel was stable, demonstrated rapid active compound release, and showed strong antibacterial and anti-acne activity.
New Student Admission for Master’s and Doctoral Programs in Pharmaceutical Sciences at USU 2026
AgendaDOCTORAL PROMOTION EXAMINATION (OPEN DEFENSE) DOCTORAL PROGRAM IN PHARMACEUTICAL SCIENCES FACULTY OF PHARMACY, UNIVERSITAS SUMATERA UTARA (Candidate): IMELDA FERENDINA
AgendaNATIONAL WEBINAR
